• EnSens ADAM17 Activity Detection Kit

EnSens® ADAM17 Activity Detection Kit Description

Pricing (select from Available Options, above):
Trial size (25 assays) $169
96 assays $675
384 assays $1039

Also available through VWR

Mix-and-Read, Fluorescence based Protease Activity detection kit. The kit includes protease selective detection reagent, fluorescent dye, reaction buffer, and substrate positive control. Protocol volume can be easily scaled up or down as needed. It is designed for fluorimetric endpoint and kinetic microplate assays. Quantifiable down to nano- and picomolar range of active protease concentrations. Upon activation, se-Red reagent produces detectable fluorescent signal in the far red region of the light spectrum, reducing background signal and increasing dynamic range. Excitation 625-635nm/ Emission 655-665nm.

Selectivity of the EnSens® ADAM17 Activity Detection Substrate: Despite the highly-overlapping substrate specificities of ADAM17 and ADAM10, EnSens® substrates are able to differentiate between the two enzymes.

EnSens ADAM Substrate Selectivity

 

 

 

 

 

 

 


Kit Components:
•EnSens® ADAM17 Activity Detection Substrate
•Far Red Fluorogen (FRF dye)
•Pre-activated substrate (EnSens®-PA, substrate positive control)
•2X Assay buffer
•Molecular biology grade water

A DISINTEGRIN AND METALLOPROTEASE 17
(ADAM17, TACE, TNF-alpha Converting Enzyme, TNF-alpha convertase, CD156b, A Disintegrin And Metalloproteinase 17)
EC 3.4.24.86

BIOLOGICAL ROLES
ADAM17/TACE is the major TNF-alpha (tumor necrosis factor alpha) sheddase. It can be either soluble or membrane-bound, and also cleaves Notch receptors, amyloid precursor protein, L-selectin, cadherins, ACE2 (angiotensin converting enzyme 2), EGFR, and TGF-alpha (transforming growth factor alpha). Thus it is involved in many important processes and diseases, such as development, inflammation, arthritis, cancer, Alzheimer’s disease, Crohn’s disease, obesity, and atherosclerosis.

EnSens ADAM17 Activity Detection Kit

  • Product Code: 032014_09
  • Availability: In Stock
  • $675.00


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Tags: ADAM17, TACE, protease, enzyme, fluorescence, activity detection, reaction buffer, metalloproteinase